Au(III)-catalyzed tandem amination-hydration of alkynes: synthesis of α-(N-2-pyridonyl)ketones.
نویسندگان
چکیده
A new Au(III)-catalyzed tandem amination-hydration reaction has been discovered, leading to the formation of α-(N-2-pyridonyl)ketones and heterocyclic analogues in good to excellent yields (14 examples, 48-90%). This reaction demonstrates the unusual use of a heterocyclic sp(2) nitrogen nucleophile in a gold-catalyzed 6-endo-dig cyclization. The tandem process allows rapid access to α-(N-2-pyridonyl)ketones, making them a convenient building block for the synthesis of more complex N-alkyl pyridone targets.
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ورودعنوان ژورنال:
- Organic letters
دوره 14 3 شماره
صفحات -
تاریخ انتشار 2012